Research in the Lybrand lab
IN VITRO MODELS OF TBI
During TBI, multiple types of mechanical forces can cause tissue damage or disrupt brain function that ultimately leads to neurological impairment. The Lybrand lab uses human cerebral organoids to further understand how pressure, shear stress, and cavitation forces disrupt the neural circuitry of the brain.
The Lybrand lab uses principles of computation neurobiology and signal processing to create network synchrony maps from multielectrode array recordings of cerebral organoids to study how mechanical forces alter neural network properties.
BRAIN REGENERATION
The brain has a limited ability to regenerate and repair itself. We use stem cell technology to build brain tissue grafts for transplantation that can regenerate damaged neural pathways and functionally recover disabilities caused by TBI.